Cybin (NYSE American: CYBN) (NEO: CYBN), a neuropsychiatry platform company, announced its first strategic partnership agreement (“SPA”) with Segal Trials as part of its multinational pivotal Phase 3 program for CYB003, targeting Major Depressive Disorder (“MDD”). Segal Trials, a South Florida-based research network specializing in psychiatry and psychedelics, joins Cybin in advancing its Phase 3 program, which aims to enroll approximately 550 patients across 40+ U.S. and European clinical sites. CEO Doug Drysdale emphasized the program’s efficiency-focused model to enhance trial operations and foster long-term partnerships. Segal Trials’ President Bonnie Segal highlighted the collaboration’s potential to accelerate research and approval of CYB003, which showed promising Phase 2 results in achieving 12-month remission for most patients.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry platform company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced the launch of its first strategic partnership agreement (“SPA”) with Segal Trials in furtherance of Cybin’s multinational pivotal Phase 3 program evaluating CYB003 for the adjunctive treatment of Major Depressive Disorder (“MDD”).

Cybin (NYSE American: CYBN) (NEO: CYBN), a clinical-stage neuropsychiatry company, summarized its 2024 accomplishments and detailed upcoming 2025 milestones. CEO Doug Drysdale highlighted advancements in its pipeline of tryptamine serotonin receptor agonists, including CYB003, a deuterated psilocin program for major depressive disorder (“MDD”), and CYB004, a deuterated dimethyltryptamine in intramuscular form for generalized anxiety disorder (“GAD”). In March 2024, CYB003 received FDA Breakthrough Therapy Designation, expediting its development and recognizing the unmet need in MDD treatment. Results from a Phase 2 study of CYB003 in MDD showed a 100% response rate and 71% remission rate, leading to the initiation of the multinational Phase 3 PARADIGM program. Additionally, a Phase 2 proof-of-concept study for CYB004 in GAD commenced. For 2025, Cybin anticipates topline data from the CYB004 Phase 2 study in early 2025 and the initiation of the EXTEND and EMBRACE components of the PARADIGM Phase 3 program.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, is pleased to provide a year-end summary of its key accomplishments in 2024 and upcoming milestones for 2025.

Cybin (NYSE Americ a n: CYBN) (NEO: CYBN) a clinical-stage neuropsychiatry company, announced that CEO Doug Drysdale will join a fireside chat at the virtual Lytham Partners 2025 Investor Healthcare Summit on Jan. 13. The live webcast begins at 11:30 a.m. ET, with an archived version accessible afterward on the company’s investor relations site.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, is pleased to announce that Doug Drysdale, Cybin’s Chief Executive Officer, will participate in a fireside chat at the Lytham Partners 2025 Investor Healthcare Summit taking place virtually on January 13, 2025.

Cybin (NYSE American: CYBN) (NEO: CYBN) presented compelling data from its clinical programs at the American College of Neuropsychopharmacology (“ACNP”) Annual Meeting, including 12-month efficacy results from its Phase 2 study of CYB003, a deuterated psilocin program for Major Depressive Disorder (“MDD”), which demonstrated a 100% response rate and 71% remission rate after two doses. Additional data from a Phase 1b study indicated that combining SPL026 (DMT fumarate) with SSRIs may enhance efficacy without requiring patients to discontinue antidepressants. Cybin also highlighted progress in its CYB004 deuterated DMT program, which is being evaluated in a Phase 2 study for Generalized Anxiety Disorder (“GAD”).

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced the presentation of two posters at the American College of Neuropsychopharmacology (“ACNP”) Annual Meeting taking place December 8-11, 2024, in Phoenix, Arizona.

Cybin (NYSE American: CYBN) (Cboe CA: CYBN) is a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options. The company has announced that its CEO Doug Drysdale and CMO Amir Inamdar, MBBS, DNB (Psych), FFPM will participate in the Water Tower Research Fireside Chat Series taking place on Wednesday, Dec. 11, 2024, at 11:00 a.m. ET. Robert Sassoon, senior analyst at Water Tower Research, will host the fireside chat, which will feature topics including: CYB003’s 12-month efficacy data from its Phase II study for the treatment of major depressive disorder and initiation of Cybin’s Phase III PARADIGM(TM) program, its design, enrollment process and milestone targets.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, is pleased to announce that Doug Drysdale, Cybin’s Chief Executive Officer, and Amir Inamdar, MBBS, DNB (Psych), FFPM, Cybin’s Chief Medical Officer, will participate in the Water Tower Research Fireside Chat Series taking place on Wednesday, December 11, 2024, at 11:00 a.m. ET.

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Cybin (NYSE American: CYBN) (NEO: CYBN) shared promising 12-month efficacy data from its Phase 2 study of CYB003, a proprietary deuterated psilocin treatment for major depressive disorder (“MDD”). Participants receiving two 16 mg doses of CYB003, three weeks apart, achieved a 100% response rate and 71% remission rate at the 12-month mark, with an average reduction of 23 points in MADRS scores. The study highlighted CYB003’s potential as a safe, effective, and durable alternative to traditional treatments, offering relief with just two doses per treatment cycle. With its Phase 3 pivotal program underway, Cybin is advancing toward regulatory approval and commercialization to address significant unmet needs in MDD care.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced unprecedented 12-month efficacy data from its Phase 2 study of CYB003, a proprietary deuterated psilocin program in development for the potential adjunctive treatment of major depressive disorder (“MDD”). As previously announced, CYB003 received Breakthrough Therapy Designation by the U.S Food and Drug Administration (the “FDA”) for this indication, which provides an expedited review pathway.

Cybin (NYSE American: CYBN) (NEO: CYBN) announced it will hold a conference call and webcast on Nov. 18, 2024, at 8 a.m. ET, led by CEO Doug Drysdale and CMO Amir Inamdar. The event will cover 12-month efficacy and safety results from its Phase 2 study of CYB003 for Major Depressive Disorder, along with an overview of the design for the Phase 3 PARADIGM program, recently launched to advance CYB003. The presentation will be followed by a Q&A session for investors.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry platform company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced that it will host a conference call and webcast on Monday, November 18, 2024 at 8:00 a.m. ET.

Cybin starts Phase 3 trials for its depression treatment, CYB003, backed by strong Phase 2 data and a solid cash position.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced the initiation of PARADIGMTM, its Phase 3 pivotal program evaluating the efficacy and safety of CYB003 for the adjunctive treatment of Major Depressive Disorder (“MDD”). The program name, PARADIGM, represents the Company's belief that CYB003 could have the potential for a paradigm shift in the treatment of depression. The Company also today reported unaudited financial results for its second quarter ended September 30, 2024.

Cybin (NYSE American: CYBN) (NEO: CYBN) has initiated its Phase 3 PARADIGM program to evaluate the efficacy and safety of CYB003, an adjunctive treatment for Major Depressive Disorder (MDD). PARADIGM includes three pivotal studies: APPROACH, EMBRACE, and EXTEND, each aimed at examining CYB003’s potential to deliver rapid and durable relief from depressive symptoms. In Phase 2, CYB003 demonstrated significant efficacy, with 75% of patients achieving remission after two doses of 16 mg. The Phase 3 studies incorporate methods to maximize retention and address challenges seen in similar treatments, with the goal of developing a novel and effective therapy for MDD. Cybin also reported its Q2 financials, with cash reserves of C$154.3 million and a net loss of C$57.2 million, driven largely by increased research and operating expenses.

Cybin (NYSE American: CYBN) (NEO: CYBN) announced that CEO Doug Drysdale will join a panel titled “The Next Frontier in Mental Health Research” at the 2024 Milken Institute Future of Health Summit in Washington, D.C., on November 13. Drysdale will discuss Cybin’s progress in developing breakthrough treatments for mental health conditions, including CYB003, a Phase 3 program targeting major depressive disorder, and CYB004, in Phase 2 for generalized anxiety disorder. Cybin joins leaders at the Summit focused on advancing health research to address mental illness with innovative, personalized treatment solutions.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry platform company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced that Doug Drysdale, Cybin’s Chief Executive Officer, will be speaking at the 2024 Milken Institute Future of Health Summit on a panel entitled “The Next Frontier in Mental Health Research.”

Cybin secures a U.S. patent for its CYB005 program targeting CNS disorders and prepares to launch a Phase 3 trial for CYB003 in major depressive disorder.

Cybin (NYSE American: CYBN) (NEO: CYBN) announced that the United States Patent and Trademark Office has granted U.S. patent 12,122,741 for the composition of matter related to lead preclinical candidates in its CYB005 phenethylamines program. This patent supports Cybin’s development of non-hallucinogenic treatments for Central Nervous System (“CNS”) disorders. Cybin is focused on expanding its portfolio beyond its clinical-stage programs, CYB003 and CYB004, by exploring the potential of non-hallucinogenic neuroplastogens and serotonin receptor agonists. CEO Doug Drysdale emphasized the significance of this patent in addressing unmet medical needs in CNS disorders while delivering long-term value to shareholders.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry platform company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, today announced that the United States Patent and Trademark Office (“USPTO”) has granted U.S. patent 12,122,741 (‘741) with claims to the composition of matter of lead preclinical candidates in the Company's CYB005 phenethylamines program.

Cybin (NYSE American: CYBN) (Cboe CA: CYBN), a clinical-stage biopharmaceutical company developing new and innovative next-generation psychedelic-based treatment options, today announced participation in the Water Tower Research Fireside Chat Series on Tuesday, October 8, 2024, at 3 p.m. ET. Cybin CEO Doug Drysdale will join the fireside chat hosted by Robert Sassoon, Senior Research Analyst at Water Tower Research.

Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN) (“Cybin” or the “Company”), a clinical-stage breakthrough neuropsychiatry company committed to revolutionizing mental healthcare by developing new and innovative next-generation treatment options, is pleased to announce that Doug Drysdale, Cybin’s Chief Executive Officer, will participate in the Water Tower Research Fireside Chat Series taking place on Tuesday, October 8, 2024, at 3:00 p.m. ET.