Silexion Therapeutics Corp - Ordinary Shares (SLXN)

PESG Research releases new market update: Silexion Therapeutics (NASDAQSLXN)* continues to strengthen its position in the precision oncology landscape with breakthrough preclinical data validating systemic administration of SIL-204, potentially opening new frontiers in treating KRAS-driven cancers. This development comes amid increasing industry appetite for innovative oncology assets, exemplified by recent multi-billion dollar acquisitions.

PESG Releases a Market Update - Silexion Therapeutics (NASDAQSLXN), a clinical-stage biotech advancing RNA interference (RNAi) therapies for KRAS-driven cancers, has reported compelling new preclinical data for SIL-204, its next-generation siRNA candidate. These findings reaffirm the company’s innovative approach to addressing some of the most challenging cancers, including pancreatic cancer, which is marked by KRAS mutations in over 90% of cases.

PESG Research Releases an Market Update Report on Silexion Therapeutics (NASDAQSLXN). The precision oncology sector has rapidly evolved into one of the most dynamic areas of cancer treatment innovation. Among the key players pioneering novel approaches is Silexion Therapeutics, a clinical-stage biotechnology company focused on RNA interference (RNAi) therapies for KRAS-driven cancers—one of the most prevalent and historically “undruggable” oncogenic drivers. Silexion’s latest announcement, detailing its collaboration with Evonik to develop an advanced siRNA PLGA microparticle formulation for SIL-204, marks another strategic milestone in its quest to transform cancer treatment. This comes as the precision oncology industry experiences rising M&A activity and robust demand for groundbreaking therapies.

Silexion Therapeutics (NASDAQSLXN) is at the forefront of neurological health, developing innovative therapies to treat brain disorders. The company will be presenting alongside world-class headliners such as Zack Kass, former Head of Go-To-Market at OpenAI where ChatGPT was created, and “Shark Tank” stars Kevin O’Leary, Robert Herjavec, and Daymond John.

Just days after a previous announcement on new Phase 2 data for their LODER technology, Silexion Therapeutics (NASDAQSLXN) has revealed new preclinical findings for its next-generation siRNA candidate, SIL-204. These latest results, focusing on the candidate's ability to target KRAS mutations in pancreatic cancer, add another layer of excitement around the company's innovative approach to tackling one of the deadliest forms of cancer.

Silexion Therapeutics Corp. (NASDAQSLXN) (“Silexion” or the “Company”), a clinical-stage biotech developing RNA interference (RNAi) therapies for KRAS-driven cancers, today announced new preclinical findings for SIL-204, its second-generation siRNA candidate, following the optimization of its extended-release formulation. These latest findings demonstrate that the latest SIL-204-microparticle formulation can inhibit the growth and induce necrosis of the human pancreatic cell line that bears the KRAS G12D mutation xenotransplanted into mice. Given that this mutation constitutes the largest segment of pancreatic cancer subtypes, it represents a significant in the development of SIL-204.

Silexion Therapeutics (NASDAQSLXN), a clinical-stage biotech company developing cutting-edge RNA interference (RNAi) therapies, has announced compelling new findings from its Phase 2 trial of LODER™ in patients with non-resectable locally advanced pancreatic cancer (LAPC). The updated data shows a 56% objective response rate (ORR) and a 67% improvement in tumor resectability, a significant step forward in treating a cancer type that has long been resistant to effective intervention. But the implications of these findings may extend beyond pancreatic cancer, potentially impacting a much broader range of KRAS-driven cancers.

Silexion Therapeutics Corp. (NASDAQSLXN) (“Silexion” or the “Company”), a clinical-stage biotech developing RNA interference (RNAi) therapies for KRAS-driven cancers, today announced significant new findings from its Phase 2 trial of LODER™ in patients with non-resectable locally advanced pancreatic cancer (LAPC) which bear the KRAS G12D or G12V mutation (approximately 70% of pancreatic cancer patients). Overall the updated analysis reveals a 56% objective response rate (ORR) in patients treated with LODER, with the ORR increasing to 67% in patients whose previously non-resectable tumors became resectable. This marks a significant step forward in potentially improving surgical outcomes for LAPC patients.

Summit Therapeutics (NASDAQSMMT) recently captured headlines with the release of its Phase 3 data for ivonescimab, a targeted NSCLC therapy that has generated substantial buzz. The results from its trial conducted in China showed a dramatic 49% reduction in the risk of disease progression or death compared to Merck’s Keytruda, signaling a potentially disruptive force in NSCLC treatment. However, the news wasn’t without its concerns—since the trial data originates from China, there are questions about its applicability to broader, global populations. As noted by BMO Capital Markets’ Evan Seigerman: “Results may or may not be generalizable beyond the China-focused patient population initially assessed.” Despite this, Summit’s valuation has risen by over 100%, now approximating $19 billion. With such a high valuation, the company could see limited room for further significant gains, leading many in the industry to explore other emerging opportunities in precision oncology.

Silexion Therapeutics (NASDAQSLXN) has emerged an intriguing yet under the radar player in the precision oncology space, focusing on developing innovative RNA interference (RNAi) therapies for KRAS-driven cancers. As a recently de-SPACed company following its merger with Moringa Acquisition Corp NASDAQ: MACANASDAQMACA)